alexa Molecular characterization of Staphylococcus aureus isolates from a 2005 clinical trial of uncomplicated skin and skin structure infections.
Pharmaceutical Sciences

Pharmaceutical Sciences

Pharmaceutica Analytica Acta

Author(s): Jones RN, Nilius AM, Akinlade BK, Deshpande LM, Notario GF

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Abstract A clinical trial of uncomplicated skin and skin structure infections (39 locations in 19 states) observed that community-associated or community-onset methicillin-resistant Staphylococcus aureus (CO-MRSA) represented 23\% of all pathogens at baseline culture and 53\% of 190 S. aureus isolates. CO-MRSA strains typically were Panton-Valentine leukocidin (PVL) positive (95\%), contained staphylococcal cassette chromosome mec type IVa (99\%), were USA300 or USA400 clones (92\%), and exhibited minimal coresistances (macrolides and/or fluoroquinolones). Clinical results remained identical (89\% cures) regardless of the antimicrobial used or CO-MRSA molecular patterns, PVL production, or antimicrobial susceptibility profiles.
This article was published in Antimicrob Agents Chemother and referenced in Pharmaceutica Analytica Acta

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