alexa Molecular epidemiology of HIV Type 1 in Ukraine: birthplace of an epidemic.
Infectious Diseases

Infectious Diseases

Journal of AIDS & Clinical Research

Author(s): Saad MD, Shcherbinskaya AM, Nadai Y, Kruglov YV, Antonenko SV,

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Abstract During the 1990s, HIV-1 spread rapidly through drug networks in Ukraine and from there throughout the former Soviet Union. To examine the origins of this epidemic, the genetics of HIV-1 in Ukraine were studied. Proviral DNA from PBMC was extracted and PCR amplified. Part of pol and nearly full genomes of HIV-1 were sequenced and characterized. The predominant genetic form in 163 strains was subtype A (66\%), followed by subtypes B (30\%), C (2\%), D (1\%), and a new AB recombinant form (1\%). HIV strains from Kiev were diverse having subtypes A, B, C, and D. In Crimea, Donetsk, Poltava, and Odessa, however, the strains were overwhelmingly subtype A, while in Nikolaev subtype B predominated. After the near simultaneous introduction of subtypes A and B in Ukraine, subtype B remained where it was introduced while subtype A spread widely, creating the fastest growing epidemic in the world. This article was published in AIDS Res Hum Retroviruses and referenced in Journal of AIDS & Clinical Research

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