alexa Molecular evidence for apoptosis in microfilariae of Wuchereria bancrofti induced by diethylcarbamazine.


Biochemistry & Physiology: Open Access

Author(s): Peixoto CA, Santos AC, Ayres CF

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Abstract Apoptosis, a programmed cell death, is characterized by chromatin condensation, numerous vacuoles, reduction in cell volume, and endonuclease cleavage DNA degradation detected in gel electrophoresis as nucleosomal ladder. Here we report that diethylcarbamazine induces DNA fragmentation in microfilariae of Wuchereria bancrofti revealed by ligation-mediated polymerase chain reaction and by in situ terminal deoxynucleotidyl transferase-mediated dUTP nick end-labeling at the light and electron transmission level. This article was published in Parasitol Res and referenced in Biochemistry & Physiology: Open Access

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