alexa Molecular Insights into the Histogenesis and Pathogenesis of Gastrointestinal Stromal Tumors.
Oncology

Oncology

Journal of Cancer Science & Therapy

Author(s): Rubin BP, Fletcher JA, Fletcher CD

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Abstract Gastrointestinal stromal tumors (GISTs) have long been problematic in terms of classification and determination of prognosis. Recent studies have suggested that GISTs differentiate toward a phenotype resembling the interstitial cells of Cajal. This has led to the important discovery that activating mutations in the KIT receptor tyrosine kinase play an important role in the pathogenesis of GISTs. These findings have helped clarify the distinction between GISTs and other mesenchymal neoplasms of the gastrointestinal tract and may translate into an improved ability to predict biologic behavior, as well as suggesting possible avenues for rational drug design for the treatment of GISTs. Int J Surg Pathol 8(1):5-10, 2000
This article was published in Int J Surg Pathol and referenced in Journal of Cancer Science & Therapy

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