alexa Molecular Mechanisms and Genome-Wide Aspects of PPAR Subtype Specific Transactivation.
Molecular Biology

Molecular Biology

Journal of Cell Science & Therapy

Author(s): Bugge A, Mandrup S

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Abstract The peroxisome proliferator-activated receptors (PPARs) are central regulators of fat metabolism, energy homeostasis, proliferation, and inflammation. The three PPAR subtypes, PPARα, β/δ, and γ activate overlapping but also very different target gene programs. This review summarizes the insights into PPAR subtype-specific transactivation provided by genome-wide studies and discusses the recent advances in the understanding of the molecular mechanisms underlying PPAR subtype specificity with special focus on the regulatory role of AF-1.
This article was published in PPAR Res and referenced in Journal of Cell Science & Therapy

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