Author(s): Gran B, Hemmer B, Vergelli M, McFarland HF, Martin R, Gran B, Hemmer B, Vergelli M, McFarland HF, Martin R
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Abstract Various mechanisms have been proposed for the initiation of autoimmune responses by autoreactive T-cell clones. One of these, the molecular mimicry hypothesis, postulates that myelin-reactive T-cell clones are activated by foreign antigens. Until recently, sequence homology between self- and foreign antigens was considered necessary for cross-recognition to occur in multiple sclerosis. This article reviews current progress in T-cell receptor immunology that led to modify this view and proposes a role for degenerate T-cell antigen recognition in the induction of autoimmunity.
This article was published in Ann Neurol
and referenced in Immunome Research