alexa Molecular modeling, synthesis and screening of some new 4-thiazolidinone derivatives with promising selective COX-2 inhibitory activity.
Medicine

Medicine

Emergency Medicine: Open Access

Author(s): UnsalTan O, Ozadali K, Piskin K, Balkan A

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Abstract In order to develop new selective cyclooxygenase-2 inhibitors, a series of novel 2-aryl-3-(4-sulfamoyl/methylsulfonylphenylamino)-4-thiazolidinones were designed. Molecular modeling studies with COX-2 enzyme were performed by using MOE program. The designed compounds with reasonable binding modes and high docking scores were synthesized. Their COX-1/COX-2 inhibitory activities were evaluated in vitro, using NS-398 and indomethacine as reference compounds. Compounds possessing methyl group (3d and 4d) on the phenyl ring exhibited highly COX-2 inhibitory selectivity and potency. Copyright © 2012 Elsevier Masson SAS. All rights reserved. This article was published in Eur J Med Chem and referenced in Emergency Medicine: Open Access

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