alexa Molecular models for shikimate pathway enzymes of Xylella fastidiosa
Biomedical Sciences

Biomedical Sciences

International Journal of Biomedical Data Mining

Author(s): Helen Andrade Arcuri, Fernanda Canduri, Jos Henrique Pereira, Nelson Jos Freitas da Silvei, Joo Carlos Camera Jr

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The Xylella fastidiosa is a bacterium that is the cause of citrus variegated chlorosis (CVC). The shikimate pathway is of pivotal importance for production of a plethora of aromatic compounds in plants, bacteria, and fungi. Putative structural differences in the enzymes from the shikimate pathway, between the proteins of bacterial origin and those of plants, could be used for the development of a drug for the control of CVC. However, inhibitors for shikimate pathway enzymes should have high specificity for X. fastidiosa enzymes, since they are also present in plants. In order to pave the way for structural and functional efforts towards antimicrobial agent development, here we describe the molecular modeling of seven enzymes of the shikimate pathway of X. fastidiosa. The structural models of shikimate pathway enzymes, complexed with inhibitors, strongly indicate that the previously identified inhibitors may also inhibit the X. fastidiosa enzymes.

This article was published in Biochemical and Biophysical Research Communications and referenced in International Journal of Biomedical Data Mining

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