alexa Molecular regulation of galectin-3 expression and therapeutic implication in cancer progression.


Clinical & Medical Biochemistry

Author(s): Wang L, Guo XL, Wang L, Guo XL

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Abstract Galectin-3, a multifunctional protein, distributes inside and outside cells and plays an important role in tumor cell adhesion, proliferation, differentiation, angiogenesis, and metastasis in multiple tumors. Changes in galectin-3 expression are commonly seen in cancer and pre-cancerous conditions. Therefore, to understand the molecular regulation of galectin-3 expression could aid the development of new approach for cancer treatment. This review summarizes different expression of galectin-3 in cancer cells and patients' serum, the regulation mechanism and the potential therapeutic targets of galectin-3 in cancer progression. Copyright © 2016 Elsevier Masson SAS. All rights reserved. This article was published in Biomed Pharmacother and referenced in Clinical & Medical Biochemistry

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