alexa Monoclonal antibody detecting a stage-specific embryonic antigen (SSEA-1) on preimplantation mouse embryos and teratocarcinoma cells
Genetics & Molecular Biology

Genetics & Molecular Biology

Journal of Stem Cell Research & Therapy

Author(s): BB Knowles, D P Aden, D Solter

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Syngeneic and xenogeneic immunizations with teratocarcinoma stem cells (1, 2, 3) and mouse embryos (4) have resulted in antisera which after appropriate absorption react with teratocarcinoma stem cells, germ cells and embryos at various stages of development as well as some adult tissues. Such sera contain antibodies to multiple antigenic determinants, which precludes precise definition of embryo stage-specific antigens. In order to circumvent this difficulty and to study the stage-specific molecules in a methodical fashion, we are producing monoclonal antibodies (5) reactive with teratocarcinoma cells and embryos. Production and characterization of one such antibody is described here.

This article was published in Curr Top Microbiol Immunol. and referenced in Journal of Stem Cell Research & Therapy

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