Author(s): Buss NA, Henderson SJ, McFarlane M, Shenton JM, de Haan L
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Abstract Over the last three decades, monoclonal antibodies have made a dramatic transformation from scientific tools to powerful human therapeutics. At present, approximately 30 therapeutic monoclonal antibodies are marketed in the United States and Europe in a variety of indications, with sales in the US alone reaching approximately $18.5 billion in 2010. This review describes how antibody engineering has revolutionized drug discovery and what are considered the key areas for future development in the monoclonal antibody therapy field. Copyright © 2012 Elsevier Ltd. All rights reserved.
This article was published in Curr Opin Pharmacol
and referenced in Journal of Proteomics & Bioinformatics