alexa Monocytes and T lymphocytes in HIV-1-positive patients express HLA-G molecule.


Journal of Antivirals & Antiretrovirals

Author(s): Lozano JM, Gonzlez R, Kindeln JM, RouasFreiss N, Caballos R,

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Abstract OBJECTIVE: To study the expression of HLA-G on peripheral blood mononuclear cells (PBMC) from HIV-1-infected individuals in order to determine whether this molecule is induced as a consequence of HIV-1 infection. DESIGN: A total of 23 HIV-positive individuals in different stages of the disease were studied. METHODS: Flow cytometric analysis and Western blot were used to measure HLA-G expression on PBMC obtained from HIV-positive and control individuals. RESULTS: Most of the monocytes obtained from HIV-1-infected individuals express HLA-G, whereas only a very low proportion of monocytes from healthy individuals express this molecule. When T lymphocytes from HIV-1 infections were studied, it was found that 30\% of them express HLA-G, whereas only 1\% were HLA-G-positive in healthy individuals. HLA-G expression was also confirmed by Western blot using specific anti-HLA-G monoclonal antibodies. CONCLUSION: The synthesis of HLA-G is increased in monocytes and certain T lymphocytes from HIV-1-infected individuals.
This article was published in AIDS and referenced in Journal of Antivirals & Antiretrovirals

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