Author(s): Hershlag A, Paine T, Cooper GW, Scholl GM, Rawlinson K,
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Abstract OBJECTIVE: To determine the effect of mechanical assisted hatching on the pregnancy rate (PR). DESIGN: A retrospective comparative analysis of hatched versus nonhatched consecutive assisted reproductive technology (ART) cycles. SETTING: A hospital-based ART program. PATIENT(S): Patients undergoing ART treatment with assisted hatching (1994-1996) were compared with patients who did not have assisted hatching (1990-1993). INTERVENTION(S): None. MAIN OUTCOME MEASURE(S): Pregnancy rate, multiple PR, and rate of monozygotic twinning. RESULT(S): With hatching, the clinical PR per ET increased from 25.2\% to 37.1\% and the multiple PR per ET increased from 6.8\% to 13.1\%. In the nonhatched series, there were no monozygotic twins compared with eight cases in the hatched series (1.2\% per ET). CONCLUSION(S): Mechanical assisted hatching increases the PR but concomitantly elevates the rate of multiple gestation and multiple gestation of high order. There is a particularly high risk of monozygotic twinning with mechanical hatching.
This article was published in Fertil Steril
and referenced in Human Genetics & Embryology