Author(s): Reddy TR, Reddy GR, Reddy LS, Meda CL, Parsa KV,
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Abstract Montmorillonite K-10 mediated MCR of anilines, arylaldehydes and ethyl-3,3-diethoxypropionate in water afforded 2,6-unsubstituted dihydropyridines depending on the nature of anilines employed. A variety of dihydropyridines were prepared by using this green methodology in good yields and montmorillonite K-10 was found to be an inexpensive and reusable catalyst. The structure elaboration of a representative compound was carried out under Heck conditions. Some of the compounds synthesized showed significant inhibition of PDE4B when tested in vitro. Docking studies indicated that one of the ester moieties of these compounds played a key role in their interactions with the PDE4B protein. Copyright © 2013 Elsevier Masson SAS. All rights reserved.
This article was published in Eur J Med Chem
and referenced in Organic Chemistry: Current Research