alexa Morphological and Biochemical Characteristics of Apoptosis Lymphocytes of Peripheral Blood in the Pathogenesis of Atopic Bronchial Asthma of Light and Serious Severity
Biomedical Sciences

Biomedical Sciences

Biology and Medicine

Author(s): Vodounon Alode Cyrille, Skibo Yulia, Aikou Nicolas, Akpona Simon, Abramova Zinaida Ivanovna

Abstract Share this page

Background: The deregulation of the apoptosis of immune-competent cell has been suggested to play a key role in the development of the inflammatory reactions in allergic diseases like asthma. This study aimed to investi- gate the particularity of apoptosis of peripheral blood lymphocytes in aller- gic asthmatic patients (light and severe persistent asthma). The study of apoptosis peripheral blood lymphocytes were assessed by electron and optic microscopes and flow cytometry.

Result: The apoptosis of the lymphocytes of asthmatics shows structural and biochemical particularities. The initial phase of the apoptosis is ex- pressed through the correlation between the number of cells with a de- crease in the mitochondrial potential and the translocation of the phosphatidylserine on the surface of lymphocytes of patients. The exten- sion of the survival of lymphocytes in asthmatics of light severity is asso- ciated with the increase of the proliferating activity on the slowdown of the apoptosis of cells. On the other hand, the increase of the rate of self-anti- bodies directed against DNA in asthma of serious severity is associated with the death of lymphocytes by means of programmed necrosis, followed by the development of the alteration of the nearby cells and the inflammatory reactions, but also the phagocytosis of the remaining cellular frag- ments and the development of the immune response, if these cellular frag- ments contain chromatin associated with antigens.

Conclusion: The results obtained (especially with the patients of serious severity) allowed to understand the impact of the apoptosis on the immu- nity of the patients and to forecast the degree of serious asthma. Further study in immunology will benefit from these findings in order to better understand the process of apoptosis in atopic bronchial asthma patients. It appears to be obvious that diseases such as cancer, autoimmune disorders may derive benefit from such studies.

  • To read the full article Visit
  • Open Access
This article was published in Research & Reviews in BioSciences and referenced in Biology and Medicine

Relevant Expert PPTs

Relevant Speaker PPTs

Recommended Conferences

Peer Reviewed Journals
 
Make the best use of Scientific Research and information from our 700 + peer reviewed, Open Access Journals
International Conferences 2017-18
 
Meet Inspiring Speakers and Experts at our 3000+ Global Annual Meetings

Contact Us

Agri, Food, Aqua and Veterinary Science Journals

Dr. Krish

[email protected]

1-702-714-7001 Extn: 9040

Clinical and Biochemistry Journals

Datta A

[email protected]

1-702-714-7001Extn: 9037

Business & Management Journals

Ronald

[email protected]

1-702-714-7001Extn: 9042

Chemical Engineering and Chemistry Journals

Gabriel Shaw

[email protected]

1-702-714-7001 Extn: 9040

Earth & Environmental Sciences

Katie Wilson

[email protected]

1-702-714-7001Extn: 9042

Engineering Journals

James Franklin

[email protected]

1-702-714-7001Extn: 9042

General Science and Health care Journals

Andrea Jason

[email protected]

1-702-714-7001Extn: 9043

Genetics and Molecular Biology Journals

Anna Melissa

[email protected]

1-702-714-7001 Extn: 9006

Immunology & Microbiology Journals

David Gorantl

[email protected]

1-702-714-7001Extn: 9014

Informatics Journals

Stephanie Skinner

[email protected]

1-702-714-7001Extn: 9039

Material Sciences Journals

Rachle Green

[email protected]

1-702-714-7001Extn: 9039

Mathematics and Physics Journals

Jim Willison

[email protected]

1-702-714-7001 Extn: 9042

Medical Journals

Nimmi Anna

[email protected]

1-702-714-7001 Extn: 9038

Neuroscience & Psychology Journals

Nathan T

[email protected]

1-702-714-7001Extn: 9041

Pharmaceutical Sciences Journals

John Behannon

[email protected]

1-702-714-7001Extn: 9007

Social & Political Science Journals

Steve Harry

[email protected]

1-702-714-7001 Extn: 9042

 
© 2008-2017 OMICS International - Open Access Publisher. Best viewed in Mozilla Firefox | Google Chrome | Above IE 7.0 version
adwords