alexa Morphology of the cardia and significance of carditis in pediatric patients.
Gastroenterology

Gastroenterology

Journal of Gastrointestinal & Digestive System

Author(s): Glickman JN, Fox V, Antonioli DA, Wang HH, Odze RD

Abstract Share this page

Abstract The morphology of the gastric cardia in children and the significance of inflammation in this region are unknown. Some investigators propose that the cardia is comprised of mucous glands at birth, whereas others suggest that mucous glands, when present, represent a metaplastic response to gastroesophageal reflux disease. The aim of this study was to evaluate the morphologic features of the cardia in a pediatric population and to determine the significance of inflammation in this region by correlating the pathologic features with clinical and endoscopic data. Routinely processed hematoxylin and eosin-stained mucosal biopsies of the cardia from 74 pediatric patients (age range 0.1-18 years; male/female ratio 0.76:1) without endoscopic evidence of Barrett's esophagus were examined for a variety of histologic features, such as the type of glandular epithelium (mucous, mixed mucous/oxyntic, oxyntic), and the amount and type of inflammation both within 1.0 mm and >1.0 mm from the squamocolumnar junction. The results were correlated with the patients' clinical symptoms and with other histologic features, such as esophagitis, gastritis, Helicobacter pylori, and the presence of goblet cells. Our results show that either pure mucous glands (81\%) or mixed mucous/oxyntic-type glands (19\%) were present within 1 mm of the squamocolumnar junction in all of the patients (100\%) in this study. Patients with mixed mucous/oxyntic glands located <1 mm from the squamocolumnar junction were more likely to have goblet cells than were patients with mucous glands alone, but they did not differ with respect to any other feature, including patient age. However, both active esophagitis and increased inflammation in the cardia correlated positively with a longer length of pure mucous glands in the gastroesophageal junction region. Of the cases with inflammation (carditis), eosinophils correlated with the presence of active esophagitis (a histologic manifestation of gastroesophageal reflux disease), whereas increased lymphocytes correlated with chronic H. pylori gastritis. In summary, a small amount of pure mucous-type glands is present in the cardia in most pediatric patients, a finding that supports a congenital origin for this type of epithelium. However, our finding of an association between length of mucosa occupied by pure mucous glands and active esophagitis suggests that injury and repair related to gastroesophageal reflux disease may contribute to expansion of the zone occupied by cardia-type mucous glands.
This article was published in Am J Surg Pathol and referenced in Journal of Gastrointestinal & Digestive System

Relevant Expert PPTs

Relevant Speaker PPTs

Recommended Conferences

Relevant Topics

Peer Reviewed Journals
 
Make the best use of Scientific Research and information from our 700 + peer reviewed, Open Access Journals
International Conferences 2017-18
 
Meet Inspiring Speakers and Experts at our 3000+ Global Annual Meetings

Contact Us

Agri, Food, Aqua and Veterinary Science Journals

Dr. Krish

[email protected]

1-702-714-7001 Extn: 9040

Clinical and Biochemistry Journals

Datta A

[email protected]

1-702-714-7001Extn: 9037

Business & Management Journals

Ronald

[email protected]

1-702-714-7001Extn: 9042

Chemical Engineering and Chemistry Journals

Gabriel Shaw

[email protected]

1-702-714-7001 Extn: 9040

Earth & Environmental Sciences

Katie Wilson

[email protected]

1-702-714-7001Extn: 9042

Engineering Journals

James Franklin

[email protected]

1-702-714-7001Extn: 9042

General Science and Health care Journals

Andrea Jason

[email protected]

1-702-714-7001Extn: 9043

Genetics and Molecular Biology Journals

Anna Melissa

[email protected]

1-702-714-7001 Extn: 9006

Immunology & Microbiology Journals

David Gorantl

[email protected]

1-702-714-7001Extn: 9014

Informatics Journals

Stephanie Skinner

[email protected]

1-702-714-7001Extn: 9039

Material Sciences Journals

Rachle Green

[email protected]

1-702-714-7001Extn: 9039

Mathematics and Physics Journals

Jim Willison

[email protected]

1-702-714-7001 Extn: 9042

Medical Journals

Nimmi Anna

[email protected]

1-702-714-7001 Extn: 9038

Neuroscience & Psychology Journals

Nathan T

[email protected]

1-702-714-7001Extn: 9041

Pharmaceutical Sciences Journals

John Behannon

[email protected]

1-702-714-7001Extn: 9007

Social & Political Science Journals

Steve Harry

[email protected]

1-702-714-7001 Extn: 9042

 
© 2008-2017 OMICS International - Open Access Publisher. Best viewed in Mozilla Firefox | Google Chrome | Above IE 7.0 version
adwords