alexa Morphoproteomic portrait of the mTOR pathway in mesenchymal chondrosarcoma.


Journal of Clinical & Experimental Pathology

Author(s): Brown RE

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Abstract Morphoproteomics is defined as the identification by immunohistochemistry of the molecular circuitry of various proteins in a tumor by noting their state of activation (translocation and phosphorylation) and correlative expressions. Such an approach can uncover or confirm potential molecular targets that may be essential to the growth, integrity, and histogenesis of a particular tumor type and that are amenable to specific therapeutic interventions. This communication illustrates the application of such an approach in depicting the mTOR pathway in mesenchymal chondrosarcoma.
This article was published in Ann Clin Lab Sci and referenced in Journal of Clinical & Experimental Pathology

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