alexa Mother-to-child transmission of HIV infection in Manaus, State of Amazonas, Brazil.


Journal of Antivirals & Antiretrovirals

Author(s): Soeiro CM, Miranda AE, Saraceni V, Lucena NO, Talhari S,

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Abstract INTRODUCTION: Reduction in the vertical transmission of HIV is possible when prophylactic measures are implemented. Our objective was to determine demographic characteristics of HIV-infected pregnant women and the rate of mother-to-child transmission of HIV in Manaus, Amazonas, Brazil. METHODS: A descriptive study was conducted using notification, and investigating data from the Notifiable Diseases Data System in the Brazilian State of Amazonas, between 2007 and 2009. RESULTS: During the study period, notification was received of 509 HIV-positive pregnant women. The vertical transmission was 9.9\% (95\% CI: 7.2-12.6\%). The mean age of women was 27 years (SD: 5.7), and the majority (54.8\%) had not completed elementary school (eighth grade). Diagnosis of HIV seropositivity was made prior to pregnancy in 115 (22.6\%) women, during prenatal care in 302 (59.3\%), during delivery in 70 (13.8\%), and following delivery in 22 (4.3\%). Four hundred four of these women (79.4\%) had had prenatal care, with 79.4\% of patients receiving antiretroviral during pregnancy and 61.9\% of the newborn infants receiving prophylaxis. In the final multivariate logistic regression model, living in urban area [OR = 0.7 (95\% CI: 0.35-0.89)] and having had prenatal care [OR = 0.1 (95\% CI: 0.04-0.24)] remained as protective factors against vertical HIV transmission in this population. CONCLUSIONS: The relevance of adequate compliance with the measures already established as being effective in guaranteeing a reduction in HIV transmission within the maternal and infant population should be emphasized.
This article was published in Rev Soc Bras Med Trop and referenced in Journal of Antivirals & Antiretrovirals

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