alexa Mouse orthologs of human olfactory-like receptors expressed in the tongue.
Pharmaceutical Sciences

Pharmaceutical Sciences

Journal of Pharmacogenomics & Pharmacoproteomics

Author(s): Gaudin JC, Breuils L, Haertl T

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Abstract Olfactory-like receptors (OLRs) have been shown previously to be expressed in adult and foetal human tongue. This prompted us to verify the hypothesis if OLRs were involved in taste perception. In the present work, the mouse orthologs of OLR genes expressed in adult and/or foetal human tongue were identified. Analysis of their genomic localization and of their primary sequence features using bioinformatics did not reveal any shared remarkable characteristic. The expression of eight of these orthologs (S25/mJCG1, K42, mJCG2, mJCG3, P2/mJCG5, P3/mJCG6, mT09m/mJCG9, K21/mTPCR85 and mTPCR06) was studied in three types of mouse papillae as well as in the olfactory epithelium. It was found that all of them are expressed in olfactory epithelium and that only three of them (S25/mJCG1, K42/mJCG2 and mTPCR06) are expressed in papillae. However, despite many efforts it was impossible to detect without ambiguity the presence of OLR mRNAs in taste receptor cells nor in surrounding tissues by in-situ hybridization. Hence, the studied OLRs very likely play in taste papillae other roles than taste perception. This article was published in Gene and referenced in Journal of Pharmacogenomics & Pharmacoproteomics

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