alexa MR cystography for bladder tumor detection.


Journal of Cancer Science & Therapy

Author(s): Beer A, Saar B, Zantl N, Link TM, Roggel R,

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Abstract The purpose of the study was to assess the diagnostic performance of MR cystography with virtual cystoscopic and multiplanar reconstructions for detection of malignant bladder tumors. Thirty-two patients with 43 bladder tumors previously confirmed by cystoscopy (mean size 2.5 cm; 0.4-9.1 cm;) were examined at 1.5 T with a three-dimensional T2-weighted turbo spin echo sequence (TR=2911 ms, TE=500 ms, echo train length 256). Virtual cystoscopic reconstructions (VC) and multiplanar reconstructions (MPR) were obtained and analyzed separately by three radiologists without knowledge of the tumor location. Intraoperative or cystoscopic findings served as standard of reference. Sensitivities and specificities were calculated using a receiver-operating characteristic analysis with five levels of confidence. Area-under-curve values were similar for MPRs (0.952), VC (0.932) and the combination of both methods (0.954). Optimal sensitivity was 92.3\% for MPR and 90.7\% for VC, respectively, with a specificity of 91.1\% for MPR and 90.4\% for VC. The combination of MPR and VC resulted in a sensitivity of 90.7\% and specificity of 94.0\%. MR cystography is a promising, completely non-invasive technique for the detection of bladder lesions with a high diagnostic performance. This article was published in Eur Radiol and referenced in Journal of Cancer Science & Therapy

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