alexa MRI assessment of the blood-brain barrier in a hamster model of scrapie.
Neurology

Neurology

Journal of Neurological Disorders

Author(s): Chung YL, Williams A, Beech JS, Williams SC, Bell JD,

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Abstract Magnetic resonance (MR) imaging in combination with gadolinium-diethylenetriaminepenta-acetic acid (Gd-DTPA) enhancement was used to investigate the integrity of the blood-brain barrier in a hamster model of scrapie (263K) during the clinical phase of the disease. The post Gd-DTPA images of the infected hamster brain showed marked enhancement, which was not present in control animals. These results suggest that blood-brain barrier function is disrupted in the clinically-affected animal.
This article was published in Neurodegeneration and referenced in Journal of Neurological Disorders

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