alexa MRI evaluation of myometrial invasion by endometrial carcinoma. Comparison between fast-spin-echo T2w and coronal-FMPSPGR Gadolinium-Dota-enhanced sequences.
Psychiatry

Psychiatry

Journal of Addiction Research & Therapy

Author(s): Nasi F, Fiocchi F, Pecchi A, Rivasi F, Torricelli P

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Abstract PURPOSE: The depth of myometrial invasion by endometrial carcinoma strongly affects the incidence of metastasis to regional nodes and influences the surgical strategies. The aim of this paper is to compare the results of FSE T2-w and Gadolinium-enhanced FMPSGR MR sequences in assessing the depth of myometrial invasion by endometrial cancer. MATERIALS AND METHODS: Forty-five women with histopathologically-proven endometrial carcinoma underwent preoperative MRI. Axial SE T1w, axial, sagittal and para-coronal FSE T2w and para-coronal Gadolinium-enhanced FMPSGR sequences were performed using a high field strength magnet (1.5T). Within one month of MR all patients underwent hysterectomy, and anatomical evaluation of the surgical specimen was done sectioning the uterus along the short axis. Based upon the results of the histological evaluation the results of the FSE T2w and Gadolinium-enhanced sequences were compared and the statistical difference between the results obtained was statistically evaluated. RESULTS: The histological evaluation showed intramucosal neoplasm in 11 patients, myometrial infiltration less than 50\% in 31 patients, myometrial infiltration more than 50\% in 12 patients and transmural cancer in 1 patient. Statistical evaluation showed that the FSE T2w sequence had a global sensitivity and specificity of 80.6\% and 87.6\%, respectively, with a mean Negative Predictive Value of 92.6\% and a mean Positive Predictive Value of 86\%. Gadolinium-enhanced FMPSPGR sequence had a global sensitivity and specificity of 90.6\% and 93.3\%, respectively, with a mean Negative Predictive Value of 96,3\% and a mean Positive Predictive Value of 88\%. The staging accuracy (chi2 test) on FMPSPGR images (95\%) was higher than that on FSE T2w images (78\%). CONCLUSIONS: In our experience Gadolinium-enhanced dynamic sequences increase the accuracy of MR imaging in diagnosing the depth of myometrial invasion. In particular they improve the visualisation of the inner myometrium, the so called subendometrial enhancing zone, whose disruption or changes are essential for diagnosing myometrial invasion. The major diagnostic advantages of the enhanced sequences were found in postmenopausal women, where visualisation of the junctional zone may be difficult in the T2w sequences. We believe that Gadolinium-enhanced dynamic sequences should be used whenever the diagnosis is unclear at FSE T2w sequences.
This article was published in Radiol Med and referenced in Journal of Addiction Research & Therapy

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