alexa Mucosal immunity in HIV infection: what can be done to restore gastrointestinal-associated lymphoid tissue function?
Microbiology

Microbiology

Journal of Antivirals & Antiretrovirals

Author(s): George MD

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Abstract PURPOSE OF REVIEW: This review describes the impact of HIV infection on gut-associated lymphoid tissue, the mechanisms for persistent gut-associated lymphoid tissue dysfunction despite effective antiretroviral therapy, and potential strategies to restore gut-associated lymphoid tissue function and promote immune reconstitution. RECENT FINDINGS: Recent studies indicate that unresolved microbial translocation and intestinal dysbiosis may continue to promote enteropathy as well as HIV-associated and non-HIV-associated conditions in many HIV patients who otherwise maintain therapeutic control of systemic viral replication. SUMMARY: Several novel therapeutic approaches to reduce intestinal inflammation and mitigate microbial translocation may hold promise for restoring gastrointestinal health and thereby increasing the efficacy of immune reconstitution in HIV-infected patients undergoing antiretroviral therapy.

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This article was published in Curr Opin Infect Dis and referenced in Journal of Antivirals & Antiretrovirals

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