alexa Multidrug resistance in cancer: role of ATP-dependent transporters.
Microbiology

Microbiology

Journal of Antimicrobial Agents

Author(s): Gottesman MM, Fojo T, Bates SE

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Abstract Chemotherapeutics are the most effective treatment for metastatic tumours. However, the ability of cancer cells to become simultaneously resistant to different drugs--a trait known as multidrug resistance--remains a significant impediment to successful chemotherapy. Three decades of multidrug-resistance research have identified a myriad of ways in which cancer cells can elude chemotherapy, and it has become apparent that resistance exists against every effective drug, even our newest agents. Therefore, the ability to predict and circumvent drug resistance is likely to improve chemotherapy. This article was published in Nat Rev Cancer and referenced in Journal of Antimicrobial Agents

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