alexa Multifunctional roles of gelsolin in health and diseases.
Molecular Biology

Molecular Biology

Journal of Cell Science & Therapy

Author(s): Li GH, Arora PD, Chen Y, McCulloch CA, Liu P

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Abstract Gelsolin, a Ca(2+) -regulated actin filament severing, capping, and nucleating protein, is an ubiquitous, multifunctional regulator of cell structure and metabolism. More recent data show that gelsolin can act as a transcriptional cofactor in signal transduction and its own expression and function can be influenced by epigenetic changes. Here, we review the functions of the plasma and cytoplasmic forms of gelsolin, and their manifold impacts on cancer, apoptosis, infection and inflammation, cardiac injury, pulmonary diseases, and aging. An improved understanding of the functions and regulatory mechanisms of gelsolin may lead to new considerations of this protein as a potential biomarker and/or therapeutic target. © 2010 Wiley Periodicals, Inc. This article was published in Med Res Rev and referenced in Journal of Cell Science & Therapy

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