Author(s): Tan B, Matsuda A, Zhang Y, Kuno A, Narimatsu H
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Abstract To survey the glycome shift in cancer, single-dot tissue glycome profiling was improved by incorporating a lectin-assisted fractionation. The differential analysis of tissue specimens from colorectal cancer patients (n = 45) revealed that unfucosylated/α2,6-sialylated glycoproteins significantly increased in patients with poor prognoses. The detailed annotation will be an indispensable supplement for cancer-related glyco-biomarker discovery.
This article was published in Mol Biosyst
and referenced in Advanced Techniques in Biology & Medicine