alexa Multi-locus sequence typing: a tool for global epidemiology.
Microbiology

Microbiology

Journal of Bacteriology & Parasitology

Author(s): Urwin R, Maiden MC

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Abstract The characterization of pathogenic isolates plays a pivotal role in the epidemiology of infectious diseases, generating the information necessary for identifying, tracking, and intervening against disease outbreaks. In 1998 multi-locus sequence typing (MLST) was proposed as a nucleotide sequence-based approach that could be applied to many bacterial pathogens. It combined developments in high-throughput sequencing and bioinformatics with established population genetics techniques to provide a portable, reproducible, and scalable typing system that reflected the population and evolutionary biology of bacterial pathogens. MLST schemes have been developed for a variety of procaryotic and eucaryotic pathogens and the data generated have contributed to both epidemiological surveillance and fundamental studies of pathogen biology.
This article was published in Trends Microbiol and referenced in Journal of Bacteriology & Parasitology

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