Author(s): BragaSilva LA, Mogami SS, Valle RS, SilvaNeto ID, Santos AL
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Abstract Secreted aspartyl peptidases (Saps) are virulence attributes produced by Candida albicans that participate in multiple aspects of the fungal biology and pathogenesis. In the present paper, we have shown that amprenavir, a peptidase inhibitor used in HIV chemotherapy, inhibited Sap2 and growth of C. albicans and also promoted ultrastructural alterations. Esterase activity, sterol content, biofilm formation and the expression of surface mannose- and sialic acid-rich glycoconjugates were also reduced by amprenavir.
This article was published in FEMS Yeast Res
and referenced in Journal of Antimicrobial Agents