Author(s): Kyle RA
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Abstract A review of 869 cases of multiple myeloma seen at the Mayo Clinic from 1960 through 1971 revealed that 98\% of patients were 40 years of age or older and that 61\% of them were males. Inital findings were bone pain in 68\% of patients, anemia in 62\%, renal insufficiency in 55\%, hypercalcemia in 30\%, a palpable liver in 21\%, and a palpable spleen in 5\%. Proteinuria was noted in 88\% and Bence Jones proteinuria was identified in 49\%. Skeletal roentgenographic abnormalities were seen in 79\%. Serum protein electrophoresis showed a spike in 76\%, hypogammaglobulinemia in 9\%, and minor or no abnormalities in 15\%, and a globulin spike was seen 75\% of the urinary electrophoretic patterns. Immunoelectrophoresis of the serum revealed a monoclonal heavy chain in 83\% and a monoclonal light chain in the serum, in 8\% (Bence Jones proteinemia). Three patients had no monoclonal protein in the serum or the urine ("nonsecretory"). Amyloidosis was found in 7\% of the patients. Follow-up information was obtained in 99.7\% ; 82\% of the 869 patients have died. Infection and renal insufficiency were the most common specific causes of death. The median survival was 20 months; 66\% of the patients were alive at 1 year and 18\% at 5 years.
This article was published in Mayo Clin Proc
and referenced in Journal of Clinical Case Reports