alexa Multiplexed detection of protein cancer markers with biobarcoded nanoparticle probes.


Advanced Techniques in Biology & Medicine

Author(s): Stoeva SI, Lee JS, Smith JE, Rosen ST, Mirkin CA, Stoeva SI, Lee JS, Smith JE, Rosen ST, Mirkin CA

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Abstract We have developed the chemistry for preparing a universal probe and the appropriate nano- and microparticle labels that can be used to do highly selective multiplexed detection of three protein cancer markers at low-femtomolar concentration in buffer and serum media. The approach relies on a new multiplexed version of the biobarcode amplification method and offers new opportunities for studying multiple protein markers in a single sample. This could lead to new forms of disease diagnosis and monitoring disease recurrence in a variety of settings. This article was published in J Am Chem Soc and referenced in Advanced Techniques in Biology & Medicine

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