Author(s): Vandenengel JE, Morse DP
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Abstract Structure-switching signaling aptamers are nucleic acids that change shape upon binding to a specific ligand. Previously, we applied a new in vitro selection strategy to isolate structure-switching RNA aptamers responsive to the aminoglycoside antibiotic tobramycin. Here, we report the results of mutational analysis, secondary structure modeling, and ligand-specificity studies that suggest a mechanism for tobramycin-triggered structure switching.
This article was published in Biochem Biophys Res Commun
and referenced in Journal of Microbial & Biochemical Technology