alexa Myasthenia gravis: past, present, and future.
Neurology

Neurology

International Journal of Neurorehabilitation

Author(s): ContiFine BM, Milani M, Kaminski HJ

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Abstract Myasthenia gravis (MG) is an autoimmune syndrome caused by the failure of neuromuscular transmission, which results from the binding of autoantibodies to proteins involved in signaling at the neuromuscular junction (NMJ). These proteins include the nicotinic AChR or, less frequently, a muscle-specific tyrosine kinase (MuSK) involved in AChR clustering. Much is known about the mechanisms that maintain self tolerance and modulate anti-AChR Ab synthesis, AChR clustering, and AChR function as well as those that cause neuromuscular transmission failure upon Ab binding. This insight has led to the development of improved diagnostic methods and to the design of specific immunosuppressive or immunomodulatory treatments.
This article was published in J Clin Invest and referenced in International Journal of Neurorehabilitation

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