Author(s): Gopalaswamy R, Narayanan S, Jacobs WR Jr, AvGay Y
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Abstract Eighteen 'eukaryotic-like' serine/threonine kinases are present in the Mycobacterium smegmatis genome. One of them encoded by the ORF 3677 demonstrates high similarity to the Mycobacterium tuberculosis protein kinase PknF. A merodiploid strain was generated, which showed reduced growth associated with irregular cell structure. The merodiploid strain displayed altered colony morphology, defective sliding motility and biofilm formation. These data indicate a role for PknF in biofilm formation, possibly associated with alterations in glycopeptidolipid composition.
This article was published in FEMS Microbiol Lett
and referenced in Journal of Microbial & Biochemical Technology