alexa Mycobacterium tuberculosis and Copper: A Newly Appreciated Defense against an Old Foe?


Mycobacterial Diseases

Author(s): Darwin KH

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Abstract Several independent studies have recently converged upon the conclusion that the human bacterial pathogen Mycobacterium tuberculosis encounters copper during infections. At least three independently regulated pathways respond to excess copper and are required for the full virulence of M. tuberculosis in animals. In this review, I will discuss the functions of the best-characterized copper-responsive proteins in M. tuberculosis, the potential sources of copper during an infection, and remaining questions about the interface between copper and tuberculosis. © 2015 by The American Society for Biochemistry and Molecular Biology, Inc.
This article was published in J Biol Chem and referenced in Mycobacterial Diseases

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