alexa Myocarditis of mixed connective tissue disease: favourable outcome after intravenous pulsed cyclophosphamide.
Clinical Research

Clinical Research

Journal of Clinical Case Reports

Author(s): Hammann C, Genton CY, Delabays A, Bischoff Delaloye A, Bogousslavsky J,

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Abstract A 30-year-old woman with mixed connective tissue disease was admitted with Wernicke's aphasia and progressive dyspnoea with chest pain. Multiple brain infarcts on a computed tomographic scan were compatible with a thromboembolic aetiology. Echocardiography showed marked hypokinesia of the posterior wall, biventricular dilatation and a decreased left-ventricle ejection fraction (40\%). A diagnosis of myocarditis was made on myocardial biopsies disclosing interstitial lymphocytic infiltrates and myocardial fibre necrosis. A treatment with steroids and monthly pulsed cyclophosphamide was introduced. The heart function rapidly improved as assessed by a left-ventricle ejection fraction of 55\% and remained stable 17 months thereafter.
This article was published in Clin Rheumatol and referenced in Journal of Clinical Case Reports

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