alexa N-{[(6-substituted-1,3-benzothiazole-2-yl)amino]carbonothioyl}-2 4-substituted benzamides: synthesis and pharmacological evaluation.


Medicinal chemistry

Author(s): Rana A, Siddiqui N, Khan SA, Ehtaishamul Haque S, Bhat MA

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Abstract A series of 1,3-benzothiazol-2-yl benzamides (11-30) were prepared in satisfactory yield and evaluated for their anticonvulsant, neurotoxicity, CNS depressant study and other toxicity studies. All the synthesized compounds were in good agreement with elemental and spectral data. Majority of the compounds were active in MES and scPTZ screen and showed the decrease in the immobility time. None of the compounds had shown neurotoxicity or liver toxicity. This article was published in Eur J Med Chem and referenced in Medicinal chemistry

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