alexa Naloxone reduces the food intake of normal human volunteers.
Genetics & Molecular Biology

Genetics & Molecular Biology

Journal of Genetic Syndromes & Gene Therapy

Author(s): Trenchard E, Silverstone T

Abstract Share this page

Abstract While there is substantial evidence that the food intake of laboratory animals in suppressed following administration of opiate antagonists, there is less known about the effects of opiate antagonists on human feeding. This study was undertaken to examine the effect of the relatively specific opiate antagonist, naloxone, on the food intake of normal human volunteer subjects. We found that naloxone, given intravenously in single doses of 0.8 and 1.6 mg under double-blind conditions to 12 healthy subjects, caused a dose-related suppression of food intake compared to placebo, maximal at 2.5 h. No effect was observed on subjective ratings of hunger, satiety, mood or arousal, or on total flu id intake. These findings suggest that endogenous opiates may play a role in the regulation of human feeding.
This article was published in Appetite and referenced in Journal of Genetic Syndromes & Gene Therapy

Relevant Expert PPTs

Relevant Speaker PPTs

Recommended Conferences

Relevant Topics

Peer Reviewed Journals
Make the best use of Scientific Research and information from our 700 + peer reviewed, Open Access Journals
International Conferences 2017-18
Meet Inspiring Speakers and Experts at our 3000+ Global Annual Meetings

Contact Us

© 2008-2017 OMICS International - Open Access Publisher. Best viewed in Mozilla Firefox | Google Chrome | Above IE 7.0 version