alexa Nanomedicine and its potential in diabetes research and practice.
Materials Science

Materials Science

Journal of Nanomedicine & Nanotechnology

Author(s): Pickup JC, Zhi ZL, Khan F, Saxl T, Birch DJ

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Abstract Nanomedicine involves measurement and therapy at the level of 1-100 nm. Although the science is still in its infancy, it has major potential applications in diabetes. These include solving needs such as non-invasive glucose monitoring using implanted nanosensors, with key techniques being fluorescence resonance energy transfer (FRET) and fluorescence lifetime sensing, as well as new nano-encapsulation technologies for sensors such as layer-by-layer (LBL) films. The latter might also achieve better insulin delivery in diabetes by both improved islet encapsulation and oral insulin formulations. An 'artificial nanopancreas' could be an alternative closed-loop insulin delivery system. Other applications of nanomedicine include targeted molecular imaging in vivo (e.g. tissue complications) using quantum dots (QDs) or gold nanoparticles, and single-molecule detection for the study of molecular diversity in diabetes pathology. Copyright 2008 John Wiley & Sons, Ltd. This article was published in Diabetes Metab Res Rev and referenced in Journal of Nanomedicine & Nanotechnology

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