alexa Nanopore biosensor for label-free and real-time detection of anthrax lethal factor.
Engineering

Engineering

Biosensors Journal

Author(s): Wang L, Han Y, Zhou S, Wang G, Guan X, Wang L, Han Y, Zhou S, Wang G, Guan X

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Abstract We report a label-free real-time nanopore sensing method for the detection of anthrax lethal factor, a component of the anthrax toxin, by using a complementary single-stranded DNA as a molecular probe. The method is rapid and sensitive: sub-nanomolar concentrations of the target anthrax lethal factor DNA could be detected in ∼1 min. Further, our method is selective, which can differentiate the target DNA from other single-stranded DNA molecules at the single-base resolution. This sequence-specific detection approach should find useful application in the development of nanopore sensors for the detection of other pathogens.
This article was published in ACS Appl Mater Interfaces and referenced in Biosensors Journal

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