alexa Natural product-like synthetic libraries.
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Medicine

Drug Designing: Open Access

Author(s): Thomas GL, Johannes CW

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Abstract There is a paucity of chemical matter suitably poised for effective drug development. Improving the quality and efficiency of research early on in the drug discovery process has been a long standing objective for the drug industry and improvements to the accessibility and quality of compound screening decks might have a significant and positive impact. In the absence of specific molecular information that can be modeled and used predicatively we are far from identifying which small molecules are most relevant to emerging biological targets such as protein-protein interactions. Natural products have been historically successful as an entry point for drug discovery and recently screening libraries are being synthesized to emulate natural product like features. Copyright © 2011. Published by Elsevier Ltd. This article was published in Curr Opin Chem Biol and referenced in Drug Designing: Open Access

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