alexa Natural regulatory T cells in infectious disease.
Food & Nutrition

Food & Nutrition

Journal of Probiotics & Health

Author(s): Belkaid Y, Rouse BT

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Abstract This review discusses the control exerted by natural CD4(+) CD25(+) regulatory T cells (natural T(reg) cells) during infectious processes. Natural T(reg) cells may limit the magnitude of effector responses, which may result in failure to adequately control infection. However, natural T(reg) cells also help limit collateral tissue damage caused by vigorous antimicrobial immune responses. We describe here various situations in which the balance between natural T(reg) cells and effector immune functions influences the outcome of infection and discuss how manipulating this equilibrium might be exploited therapeutically. This article was published in Nat Immunol and referenced in Journal of Probiotics & Health

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