Author(s): Schimberni M, Morgia F, Colabianchi J, Giallonardo A, Piscitelli C,
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Abstract OBJECTIVE: To determine the role of the natural cycle for in vitro fertilization (IVF) in poor responder patients. DESIGN: Retrospective survey. SETTING: Private center for assisted reproduction. PATIENT(S): 294 women who were poor responders in a previous IVF cycle. INTERVENTION(S): Analysis of 500 consecutive natural cycles IVF. MAIN OUTCOME MEASURE(S): Number of cycles with oocytes, pregnancy rate per cycle, per transfer, and implantation rate. RESULT(S): Oocytes were found in 391 cases (78.1\%), and cleaving embryos suitable for transfer were obtained in 285 cycles (57.0\%). Pregnancy was observed in 49 cases, with a pregnancy rate of 9.8\% per cycle, 17.1\% per transfer, and 16.7\% per patient. The patients were subdivided arbitrarily by the women's age into three groups. Patients 35 years old or younger showed a pregnancy rate of 18.1\% per cycle, 29.2\% per transfer, and 31.7\% per patient. Women aged between 36 and 39 years showed a pregnancy rate of 11.7\% per cycle, 20.6\% per transfer, and 20.3\% per patient. Women 40 years old or older showed a pregnancy rate of 5.8\% per cycle, 10.5\% per transfer, and 9.7\% per patient. No differences were found for any of the evaluated parameters, independent of which cycle was the first, the second, third, fourth, or fifth, or further consecutive cycle. CONCLUSION(S): In poor responder patients, natural-cycle IVF is an effective treatment, especially in younger women.
This article was published in Fertil Steril
and referenced in Reproductive System & Sexual Disorders: Current Research