alexa Need for improvements in the surveillance and management of chronic viral hepatitis in HIV patients followed in a Danish outpatient clinic.
Infectious Diseases

Infectious Diseases

Journal of AIDS & Clinical Research

Author(s): Andersen KL, Larsen CS, Petersen MS, Leutscher PD, Andersen KL, Larsen CS, Petersen MS, Leutscher PD

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Abstract OBJECTIVES: The aim of this study was to assess hepatitis B virus (HBV) and hepatitis C virus (HCV) surveillance and management in HIV patients currently followed in an outpatient clinic at a Danish University Hospital. METHODS: Patient data, including demographic characteristics, clinical findings, and hepatitis serology, were reviewed at baseline. Patients with incomplete or non-updated serology within the last 2 y were retested in the next 6 months, and the results were reviewed again at follow-up. RESULTS: At baseline, 84\% and 74\% of the 574 HIV patients were found to have incomplete and/or non-updated HBV and HCV serology, respectively. At follow-up, updated HBV serology was achieved in 535 (93\%) patients; 15 (3\%) patients were found to have a chronic active infection and 156 (27\%) had a resolved infection, whereas 65 (11\%) were vaccinated against HBV and 299 (52\%) were non-immune. No patients were found to have developed chronic HBV infection following HIV diagnosis (equal to 3649 patient-y). Updated HCV serology revealed that 25 (4\%) had a chronic active HCV infection and 15 (3\%) had a resolved HCV infection. The anti-HCV incidence rate was 0.27/100 patient-y. A liver pathology assessment had not been performed within the last 2 y in 80\% of the HBV and 32\% of the HCV co-infected patients. CONCLUSIONS: Hepatitis screening and assessment had been inadequately performed. New cases of chronic hepatitis seem to occur infrequently. However, a more proactive hepatitis surveillance and management strategy integrated into the overall HIV health care program is warranted. This article was published in Scand J Infect Dis and referenced in Journal of AIDS & Clinical Research

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