alexa Nefazodone in out-patient treatment of inhaled cocaine dependence: a randomized double-blind placebo-controlled trial.
Microbiology

Microbiology

Journal of Antivirals & Antiretrovirals

Author(s): Passos SR, Camacho LA, Lopes CS, dos Santos MA

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Abstract AIMS: To assess the efficacy of oral nefazodone in the treatment of cocaine dependence. DESIGN: A 10-week randomized double-blind clinical trial was performed. METHODS: All 210 subjects fulfilled Diagnostic and Statistical Manual version IV (DSM-IV) criteria for cocaine dependence and were assigned randomly to 300 mg/day of oral nefazodone (N) or placebo (P). Self-reported drug use, retention interval in treatment, adherence to prescription and depressive symptoms were assessed by the Hamilton scale. FINDINGS: Abstinence from cocaine for 3 weeks or more was achieved by 49.5\% (N) and 45.7\% (P) (P = 0.58), but 16.2\% (N) and 22.9\% (P) used other drugs during abstinence. The average interval to resumption of drug use was 33.9 days (N) and 36.1 days (P). Adverse effects were reported by 45.8\% (N) and 29.5\% (P) (P = 0.01). Treatment for these events was needed more often in N (24.0\%) than in P (9.5\%) (P < 0.02). CONCLUSIONS: These results do not support the indication of nefazodone for out-patient treatment of inhaled cocaine dependence with or without other associated drug dependence diagnoses. This article was published in Addiction and referenced in Journal of Antivirals & Antiretrovirals

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