alexa Negative inotropic effects of cytokines on the heart mediated by nitric oxide.
Clinical Research

Clinical Research

Journal of Clinical Research & Bioethics

Author(s): Finkel MS, Oddis CV, Jacob TD, Watkins SC, Hattler BG

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The direct effects of pro-inflammatory cytokines on the contractility of mammalian heart were studied. Tumor necrosis factor alpha, interleukin-6, and interleukin-2 inhibited contractility of isolated hamster papillary muscles in a concentration-dependent, reversible manner. The nitric oxide synthase inhibitor NG-monomethyl-L-arginine (L-NMMA) blocked these negative inotropic effects. L-Arginine reversed the inhibition by L-NMMA. Removal of the endocardial endothelium did not alter these responses. These findings demonstrate that the direct negative inotropic effect of cytokines is mediated through a myocardial nitric oxide synthase. The regulation of pro-inflammatory cytokines and myocardial nitric oxide synthase may provide new therapeutic strategies for the treatment of cardiac disease.

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This article was published in Science and referenced in Journal of Clinical Research & Bioethics

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