alexa Neoadjuvant chemotherapy in invasive bladder cancer: update of a systematic review and meta-analysis of individual patient data advanced bladder cancer (ABC) meta-analysis collaboration.
Molecular Biology

Molecular Biology

Journal of Cytology & Histology

Author(s): Advanced Bladder Cancer A

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Abstract OBJECTIVES: To update a systematic review and meta-analysis that assesses the effect of neoadjuvant chemotherapy in the treatment of patients with invasive bladder cancer. METHODS: Following a prespecified protocol, we analysed updated individual patient data from all eligible randomised controlled trials that compared neoadjuvant chemotherapy plus local treatment with the same local treatment alone. RESULTS: Updated results are based on 11 trials, 3005 patients; comprising 98\% of all patients from known eligible randomised controlled trials. We found a significant survival benefit associated with platinum-based combination chemotherapy (HR = 0.86, 95\% CI 0.77-0.95, p = 0.003). This is equivalent to a 5\% absolute improvement in survival at 5 years. There was also a significant disease-free survival benefit associated with platinum-based combination chemotherapy (HR = 0.78 95\% CI 0.71-0.86, p < 0.0001), equivalent to a 9\% absolute improvement at 5 years. CONCLUSIONS: These results provide the best available evidence in support of the use of neoadjuvant platinum-based combination chemotherapy. This article was published in Eur Urol and referenced in Journal of Cytology & Histology

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