Author(s): Ridge JP, Fuchs EJ, Matzinger P
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Abstract For some time it has been thought that antigenic challenge in neonatal life is a tolerogenic rather than immunogenic event. Reexamination of the classic neonatal tolerance experiments of Billingham, Brent, and Medawar showed that tolerance is not an intrinsic property of the newborn immune system, but that the nature of the antigen-presenting cell determines whether the outcome is neonatal tolerance or immunization.
This article was published in Science
and referenced in International Journal of Inflammation, Cancer and Integrative Therapy