alexa Nephropathy in newly diagnosed type 2 diabetics with special stress on the role of hypertension.


Clinical & Medical Biochemistry

Author(s): Agarwal N, Sengar NS, Jain PK, Khare R

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Abstract OBJECTIVE: Nephropathy is a common complication in diabetes mellitus (DM), with significant morbidity and mortality. The aim of the present study is to study the incidence of nephropathy in newly diagnosed type 2 diabetics and to study the relationship of development of nephropathy with various risk factors associated with DM, like age, sex, blood pressure, blood sugar, body mass index (BMI). MATERIAL AND METHODS: We analysed 300 newly diagnosed type 2 diabetics (diagnosed within 6 months), between Jan 2008 to August 2009. Presence of urinary microalbuminuria in two samples in a period of six months was taken as criteria for detecting nephropathy. RESULTS: Incidence of nephropathy in newly diagnosed type 2 diabetics was 17.34\% (52/300). It increased significantly with increase in age and was 30\% in age group >60 years. It also has significant correlation with male sex and blood pressure with incidence of nephropathy being as high as 66.67\% at BP> 160/100 mmHg. The incidence also increased with increase in BMI as well as HbA1C. Dyslipidemia also has significant effect. All results were statistically proven. Family history of DM has only little effect. CONCLUSION: Incidence of nephropathy in newly diagnosed type 2 diabetics is as high as 17.34\%. Hypertension is the most important associated factor contributing to development of nephropathy in these patients. Poor glycemic control (high HbA1C), high BMI, dyslipidemia, age, male sex also play significant role. Family history of DM seems to have little effect.
This article was published in J Assoc Physicians India and referenced in Clinical & Medical Biochemistry

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