alexa Nerve regeneration and wound healing are stimulated and directed by an endogenous electrical field in vivo.
General Science

General Science

Biological Systems: Open Access

Author(s): Song B, Zhao M, Forrester J, McCaig C, Song B, Zhao M, Forrester J, McCaig C

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Abstract Biological roles for naturally occurring, extracellular physiological electric fields have been proposed over the past century. However, in the molecular era, many biologists presume that electric fields have little physiological relevance because there has been no unequivocal demonstration of their importance at the single-cell level in vivo. We have used an in vivo rat corneal model, which generates its own endogenous electric field and show that nerve sprouting, the direction of nerve growth and the rate of epithelial wound healing are controlled coordinately by the wound-induced electric field. This article was published in J Cell Sci and referenced in Biological Systems: Open Access

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