Author(s): Pothoulakis C, Castagliuolo I, LaMont JT
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Abstract Experiments in intact animals exposed to enterotoxins demonstrate that neurons and immune cells of the lamina propria regulate toxin-induced diarrhea and tissue damage. Clostridium difficile toxins cause profound diarrhea and acute inflammation by activating a complex cascade initiated by toxin binding to enterocyte receptors.
This article was published in News Physiol Sci
and referenced in Journal of Clinical & Experimental Dermatology Research